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AAP Grand Rounds 4:19-20 (2000) Sunscreen May Reduce Development of NeviSource: Gallagher RP, Rivers JK, Lee TK, et al. Broad-spectrum sunscreen use and the development of new nevi in white children: a randomized controlled trial. JAMA. 2000;283:29552960.
The presence of acquired melanocytic nevi is a strong risk factor for cutaneous malignant melanoma in white populations. These nevi begin in childhood and are mainly caused by sun exposure. Investigators from British Columbia conducted a randomized trial from 19931996 to determine whether use of a broad-spectrum, high-SPF sun-screen attenuates the development of nevi in white children. Children in grades 1 and 4 were randomly assigned to either a treatment group (n=222) that received SPF 30 broad-spectrum sunscreen and instructions to apply it
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