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AAP Grand Rounds 4:41-42 (2000)
© 2000 American Academy of Pediatrics

EPIDEMIOLOGY

New Agent Decreases Stool Output and Duration of Illness in Acute Diarrhea

Source: Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, et al. Racecadotril in the treatment of acute watery diarrhea in children. N Engl J Med. 2000;343:463–467.

The first 20% of the full text of this article appears below.

Acute diarrhea is a common illness in childhood. Occasionally, oral rehydration fails and a child must be given IV fluid replacement therapy. Rarely, diarrhea leads to hypotonic shock and death, especially in underdeveloped nations. In this study, researchers in Peru addressed the question of whether racecadotril (acetorphan), which decreases intestinal hypersecretion but not intestinal motility, can decrease stool volume and duration of illness in acute watery diarrhea in children. They studied 135 boys aged 3–35 months who were hospitalized for dehydration from watery diarrhea. They studied only boys because . . . [Full Text of this Article]

Brett W. Robbins, MD, FAAP
Internal Medicine and Pediatrics, University of Rochester, Rochester, NY