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AAP Grand Rounds 4:44-45 (2000)
© 2000 American Academy of Pediatrics

ALLERGY/IMMUNOLOGY

Exposure to Siblings, Day Care Decreases Risk of Childhood Asthma

Source: Ball TM, Castro-Rodriguez JA, Griffith KA, et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med. 2000;343:538–543.

The first 20% of the full text of this article appears below.

A number of hypotheses have been proposed to explain the rising incidence and prevalence of asthma. In this study, Ball et al evaluated the effects of day care attendance and family size on the future development of childhood asthma in a large cohort of Tucson, AZ, children that had been followed from birth to age 13 years. The study evaluated the possible relationship of a physician diagnosis of asthma between the ages of 6 and 13 years and the prevalence of frequent wheezing, defined as more than 3 wheezing episodes in the previous year, with the number of older siblings at home and attendance at day care during infancy.

In this cohort of 1,035 children, the presence of 1 or more older siblings at home was found to have a protective effect against . . . [Full Text of this Article]

Robert Alan Wood, MD, FAAP
Johns Hopkins Hospital, Baltimore, MD