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AAP Grand Rounds 4:45-46 (2000) Simple Household Measures May Prevent Asthma in High Risk InfantsSource: Chan-Yeung M, Manfreda J, Dimich-Ward H, et al. A randomized controlled study of the effectiveness of a multi-faceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med. 2000;154:657663.
This large (n=545) prospective randomized trial at 2 universities in Canada addressed the question of whether avoidance of typical asthma triggers would decrease the incidence of asthma in the first year of life. Unborn infants at high risk for asthma (1 first degree relative with asthma or 2 first degree relatives with IgE-mediated allergic disease) were identified before birth and randomized into 2 groups. The intervention group received mattress covers and had their carpets treated with benzyl benzoate powder to decrease exposure to dust mite allergens. They were also encouraged to remove furry pets from the home, not smoke, avoid day care, and breastfeed for at least 4 months. Those who could not breastfeed were given a partially hydrolyzed whey formula. Research nurses using a modified version of the European Community Respiratory Health Survey1 conducted home visits at 2 weeks and 4,
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