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AAP Grand Rounds 4:60 (2000)
© 2000 American Academy of Pediatrics

ANESTHESIOLOGY

Amnesia Following Oral Midazolam in Children

Source: Kain ZN, Hofstadter MB, Mayes LC, et al. Midazolam: effects on amnesia and anxiety in children. Anesthesiology. 2000;93:676–684.

The first 20% of the full text of this article appears below.

The authors undertook to determine the minimum time needed to cause anterograde amnesia in children following oral administration of midazolam. The study children involved were patients aged 5–10 years at Yale University Hospital’s outpatient surgery center scheduled to undergo surgical procedures lasting 2 hours or less. Eighty children received 0.5 mg/kg of midazolam, while 33 patients in the control group received a placebo. Memory tests after midazolam were given 5, 10 and 20 minutes after the dose. The control group was tested 15 . . . [Full Text of this Article]

Thomas Mancuso, MD, FAAP
Anesthesiology, Children’s Hospital, Boston, MA