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 Vol. 5 No. 2, February 2001
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AAP Grand Rounds 5:10 (2001)
© 2001 American Academy of Pediatrics

RHEUMATOLOGY

Cutaneous Neonatal Lupus Without Heart Block: Risks for Mother, Infant, and Future Siblings

Source: Neiman AR, Lee LA, Weston WL, Buyon JP. Cutaneous manifestations of neonatal lupus without heart block: characteristics of mothers and children enrolled in a national registry. J Pediatr. 2000;137:674–680.[Medline]

The first 20% of the full text of this article appears below.

Demographics of infants with cutaneous neonatal lupus (NLE) were examined in this retrospective record review from the Research Registry for Neonatal Lupus. Patients were defined as having NLE if they met 2 criteria: (1) heart block or characteristic rash and (2) maternal antibodies to SSA/Ro, SSB/La or U1RNP (in skin rash alone). This study describes characteristics of 47 mothers of 57 infants (20 boys) with cutaneous NLE who had cutaneous manifestations of NLE without congenital heart block (CHB). The health status of the mothers of children with cutaneous NLE was similar to those mothers of children with CHB. Thirty-four mothers had rheumatic symptoms or diagnoses: 7 Sjogren’s syndrome (SS), 9 systemic lupus erythematosis (SLE), 6 SLE/SS, 1 rheumatoid arthritis/SS and 11 with undifferentiated autoimmune syndrome (UAS); 20 of these mothers reported photosensitivity. Thirteen (28%) . . . [Full Text of this Article]

Susan H. Ballinger, MD
Rheumatology, James Whitcomb Riley Hospital, Indiana University School of Medicine, Indianapolis, IN