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 Vol. 6 No. 2, August 2001
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AAP Grand Rounds 6:14-15 (2001)
© 2001 American Academy of Pediatrics

INFECTIOUS DISEASES

Doxycycline Prophylaxis for Lyme Disease

Source: Nadelman RB, Nowakowski J, Fish D, et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med. 2001;345:79–84.[Abstract/Free Full Text]

The first 20% of the full text of this article appears below.

In Westchester County, NY, an area hyperendemic for Lyme disease, Nadelman et al conducted a randomized, double-blind, placebo-controlled study to examine the effectiveness of oral doxycycline for preventing Lyme disease following a tick bite. They enrolled 506 subjects ≥12 years of age between May 1987 and December 1996. To be enrolled in the study subjects had to have an attached Ixodes scapularis tick removed within the preceding 72 hours and have the tick available both for identification by a medical entomologist and for estimation of duration of attachment by assessing the degree of engorgement (flat or unfed vs engorged or partially fed). Candidates were excluded if they had clinical signs of Lyme disease, were taking or had just completed a course of antibiotics effective against Borrelia burgdorferi, were pregnant or lactating, or had been vaccinated against Lyme disease.

Subjects were evaluated at enrollment, and 3 and 6 weeks later. Blood specimens were collected at these times to look for serologic . . . [Full Text of this Article]

Mobeen H. Rathore, MD, FAAP1 and Leslie L. Barton, MD, FAAP2
1 Pediatrics, University of Florida Health Science Center, Jacksonville, FL
2 Pediatrics, University of Arizona School of Medicine, Tucson, AZ