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In pyloric stenosis, the muscular antropyloric portion of the gastrointestinal tract is abnormally thickened. While progress has been made in diagnosis and treatment of idiopathic hypertrophic pyloric stenosis (IHPS), its etiology remains mysterious. The thickening of the antropyloric portion of the stomach and crowding of redundant and edematous mucosa within the lumen causes obstruction to the passage of gastric contents. The thickened muscle of the pylorus is depleted of inhibitory peptides such as vasoactive intestinal polypeptide, synaptic vesicles, presynaptic terminals, and neural cell adhesion …
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