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A cohort study was performed by the Danish Epidemiology Science Centre, Copenhagen, to evaluate whether vaccinations have contributed to the increasing prevalence of type 1 diabetes mellitus (DM1). Investigators evaluated detailed information on vaccinations and DM1 in a cohort comprising all 739,694 children born in Denmark from January 1, 1990 through December 31, 2000. The authors used Poisson regression models and estimated rate ratios according to vaccination status and number of doses. They also estimated rate ratios during each of the 4 years after vaccination to determine whether there was a clustering of DM1 cases at …
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