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Inhalation therapy using a pressurized metered-dose inhaler (MDI) with a valved holding chamber (VHC) has been shown to be at least as effective as medication delivered via a jet nebulizer.1,2 With the addition of a mask, this technique can be used in infants and young children. How much drug reaches the child’s airways will depend in part on mask seal, dead space volume of the mask and the VHC, and force applied. Researchers from the Wake Forest University School of Medicine in Winston-Salem, NC, studied the force-dependent dead space volume of 7 common pediatric face masks …
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