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Rotavirus disease kills approximately 600,000 children each year in developing countries and accounts for about one-third of hospitalizations for diarrhea world-wide.1–3 An effective vaccine has been sought for decades, but the first US licensed vaccine (RotaShield) was removed from the market in 1999 because intussusception was found in an estimated 1 per 10,000 vaccine recipients.1,2 During a 10-month period, before the RotaShield vaccine was withdrawn, a series of 3 vaccinations were given to some US infants.4 The investigators for the present case-control study from 3 pediatric centers and the Centers for Disease Control report on the effectiveness and …
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