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Investigators from the Royal Alexandra Hospital for Children, Sydney, Australia, reviewed the long-term neuroradiologic, developmental, and psychological sequelae of 41 infants (30 boys, 11 girls) diagnosed with macrocephaly at a family health service visit between 1985 and 1986. Macrocephaly was defined as an occipital-facial circumference (OFC) >95th percentile for age. After initial presentation at a mean age of 8 months (range 3–30 months), all participants received a CT or MRI of the head, and neurologic re-examinations with OFC measurements over a mean duration of 27 months. Fifteen of the original 41 patients who gave consent were re-examined at a mean age of 18 years …
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