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Researchers from Canada and the United Arab Emirates collaborated in a prospective, randomized, double-blind, controlled, multicenter investigation to determine whether nebulized 3% hypertonic saline (HS) therapy of infants hospitalized with moderately severe bronchiolitis would result in shorter length of stay (LOS) compared with a control group receiving standard therapy without HS.
Infants were eligible for enrollment if they were admitted to the hospital for treatment of moderately severe bronchiolitis, defined as a history of a preceding viral upper respiratory infection, the presence of wheezing or crackles, plus either SaO2 <94% on room air or significant respiratory distress as measured by …
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