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PICO
Question: Among children with acute otitis media due to Streptococcus pneumoniae, does exposure to PCV7-vaccine result in a greater likelihood of antimicrobial-resistant organisms?
Question type: Descriptive
Study design: Prospective cohort, observational study
Within three years of the introduction of a pneumococcal 7-valent conjugate vaccine (PCV7) in 2000, reports began to appear of increasing isolation of non-PCV7 serotypes of pneumococci from children with both invasive disease and otitis media.1,2
Investigators from the University of Rochester and the Legacy Pediatrics practice group prospectively monitored Streptococcus pneumoniae serotypes and antibiotic susceptibility following the introduction of PCV7 vaccine.
Two populations of healthy six-to 36-month-old children from a suburban private practice were monitored during three consecutive respiratory illness seasons from 2003–2006. The first group consisted of children who were having their first or second episode of acute otitis media (AOM) in their life and the second …
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