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The Adult US Acute Liver Failure (ALF) Study Group was founded in 1997 to define the epidemiology and management of patients with ALF. The group includes individuals from 23 prominent liver transplant centers.
To more uniformly manage patients with ALF at participating centers, the Group convened in 2005 to review the available literature on the management of ALF, to compare the intensive care of patients with intracranial hypertension of various etiologies, and to compare practices within participating centers.
Investigators in specialties outside of hepatology were invited to participate in formulating a standard study-wide management protocol. The present protocol expounds on a previous position paper sanctioned by the American Association for the Study of Liver Disease to offer general guidelines for management of adult patients with ALF.
The Group recommends patients with acute liver injury and hepatocellular insufficiency, defined as an international normalized ratio (INR; the ratio of a patient’s prothrombin time to a …
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