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Riddle and colleagues systematically reviewed the efficacy and safety of 3 classes of medications used to treat various psychopathologies in children and adolescents: anxiolytic medications (including benzodiazepines, buspirone, and other serotonin 1A agonists), adrenergic agents (beta-blockers and the alpha 2-adrenergic agonists clonidine and guanfacine), and the opiate antagonist naltrexone. All available controlled trials and selected uncontrolled studies of these medications in children and adolescents published in English through 1997 were reviewed. Other classes of drugs used as anxiolytics, eg, tricyclic antidepressants1 and selective serotonin reuptake inhibitors,2 are reviewed in other articles in this journal issue.
The authors found virtually no controlled data to support the efficacy of most of these drugs in the treatment of psychiatric disorders in children and adolescents. For some drugs, eg, buspirone and guanfacine, no controlled studies …
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