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Children from the United Kingdom admitted to the hospital during a 5-month study period with acute asthma were enrolled in a randomized, controlled study. Patients were excluded if they were less than 3 years, needed intravenous beta agonist therapy, couldn’t use a spacer mouthpiece effectively or were readmitted during the 5-month study period. Thirty-three control children (mean age, 8 years) received nebulized salbutamol (5 mg up to hourly by jet nebulizer driven by oxygen at 6–8 L/min) while 29 children (mean age, 6.9 years) received salbutamol from a metered dose …
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