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PICO
Question: Do children with Down syndrome and autism demonstrate regression at the same time as other children with autism?
Question type: Prognosis
Study design: Case-control
Investigators from Cincinnati Children’s Hospital Medical Center; Greenvale Hospital System Children’s Hospital, South Carolina; University of Kentucky College of Medicine; and Cincinnati College of Medicine retrospectively studied autistic regression, defined as deterioration of a previously acquired skill, in children with autism with and without Down syndrome.
All children were diagnosed by DSM IV-TR criteria, confirmed using the Autism Diagnostic Interview-Revised (ADI-R), and evidence of regression.
Children …
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