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PICO
Question: In patients with poorly controlled asthma, can treatment of asymptomatic gastroesophageal reflux improve asthma control?
Question type: Intervention
Study design: Randomized, double-blind, controlled trial
Investigators from multiple institutions in the US and Canada conducted a randomized controlled trial to determine whether proton-pump inhibitors (PPI) can improve symptoms in adults with poorly controlled asthma who have no prior history of significant gastroesophageal reflux (GER). Study participants were recruited from 19 clinical centers between 2004 and 2008.
Inclusion criteria included an age of 18 years or greater; a diagnosis of asthma by a physician and a confirmation of the diagnosis with a positive methacholine challenge or documentation of a 12% increase in the FEV1 after the use of a bronchodilator; at least eight weeks of stable use of an inhaled corticosteroid; and poor asthma control as defined …
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