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PICO
Question: Among children and adolescents who experience sudden death, what risk can be attributed to exposure to stimulant medication?
Question type: Harm
Study design: Case control
Investigators from Columbia University and the New York State Psychiatric Institute evaluated the association between stimulant use and sudden unexplained death in children and adolescents. Study children were identified through mortality data from state vital statistics (1985–1996) in 45 states plus the District of Columbia.
Cases were defined as children aged 7 to 19 years with a sudden unexplained death or death due to cardiac dysrhythmia. Controls were children who died as passengers in motor vehicle accidents, matched one-to-one with cases based on age, year of death, sex, and source of data about medication use. Data on medication use came from surveys …
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