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PICO
Question: Among female survivors of childhood cancer, what is the impact of cancer treatment on fertility?
Question type: Harm/prognosis
Study design: Retrospective cohort study
To assess effects on fertility, investigators from multiple institutions utilized data from the Childhood Cancer Survivor Study (CCSS) to identify women who had received treatment for cancer as a child or adolescent. The CCSS is a multi-institutional, National Cancer Institute-sponsored retrospective cohort study consisting of 20,720 survivors of childhood cancer diagnosed between 1970 and 1986 and greater than five years out from completion of treatment.
Data from 5,149 questionnaires returned from females aged 15 to 45 years who did not undergo surgical sterilization were analyzed. The nearest-age female siblings of these women were recruited and served as controls (n=1,441). Medical …
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