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PICO
Question: In infants with bronchiolitis, is the combination of nebulized epinephrine and oral dexamethasone an effective treatment compared to either medication alone?
Question type: Intervention
Study design: Multicenter, double-blind, placebo-controlled study
Investigators from Pediatric Emergency Research Canada (PERC) conducted a double-blind, placebo-controlled trial in which infants with bronchiolitis seen in eight emergency departments (ED) were studied to determine the benefit of using both nebulized epinephrine and corticosteroids compared to placebo or either medication alone. Infants aged 6 weeks to 12 months with bronchiolitis who were seen between 2004 and 2007 were eligible for this study if they had a score of 4–15 on the respiratory distress assessment index (RDAI).1 The RDAI rates wheezing and respiratory distress on a scale from 0–17, with a score below 4 …
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