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PICO
Question: Among children less than 4 years old who have had general anesthesia, what is the risk of the development of learning disabilities?
Question type: Harm/causation
Study design: Retrospective birth cohort study
Researchers at the Mayo Clinic, Rochester, MN, sought to determine if exposure to anesthetics might adversely affect the development of young children. They retrospectively studied the association between general anesthetic exposure before age 4 years and the development of learning disabilities (LD) in a population-based cohort consisting of children born in Olmstead County, MN, between 1976 and 1982 who remained in that county until age 5.
The records of the Rochester Epidemiology Project, which maintains records of all medical and surgical procedures done at all Rochester medical facilities, were reviewed. Educational records were used to identify children classified as having LD (>1.75 SD below the predicted standard score) in …
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