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PICO
Question: Among patients undergoing clean-contaminated surgery, does preoperative skin cleansing with chlorhexidine-alcohol result in decreased rates of postoperative infection compared to cleansing with povidone-iodine?
Question type: Intervention
Study design: Prospective, randomized trial
Researchers from multiple institutions conducted a randomized trial in adult patients to compare the rate of postoperative surgical-site infections following preoperative skin cleansing with either 2% chlorhexidine gluconate and 70% isopropyl alcohol or 10% povidone-iodine. The study was performed at six university-affiliated hospital sites in the US between 2004 and 2008. Eligible study patients were undergoing clean-contaminated surgery (ie, colorectal, small intestinal, gynecologic, or urologic surgery under controlled conditions with minimal spillage and not encountering infected urine or bile1). The primary …
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