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PICO
Question: In children with difficult-to-treat head lice infestation, what is the efficacy and safety of ivermectin compared to malathion?
Question type: Intervention
Study design: Multicenter, clusterrandomized, double-blind controlled study
Investigators from France, the UK, and Germany participated in a multicenter trial comparing oral ivermectin and malathion lotion to treat patients with head lice not eradicated by topical insecticide (pyrethroids and/or malathion) used two to six weeks before enrollment. Inclusion in the study required visual observation of lice after fine-toothed combing confirmed by study staff. Participants were at least 2 years of age and 15 kg in weight. Once an eligible child was identified, all infested members of the household (a cluster of up to six) were randomly assigned to a treatment …
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