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American Academy of Pediatrics
Senior Members

Difficult-to-Treat Head Lice

AAP Grand Rounds June 2010, 23 (6) 70; DOI: https://doi.org/10.1542/gr.23-6-70
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Source: Chosidow O, Giraudeau B, Cottrell J, et al. Oral ivermectin versus malathion lotion for difficult-to-treat head lice. N Engl J Med. 2010; 362( 10): 896– 905; doi: 10.1056/NEJMoa0905471OpenUrlCrossRefPubMed

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Question: In children with difficult-to-treat head lice infestation, what is the efficacy and safety of ivermectin compared to malathion?

Question type: Intervention

Study design: Multicenter, clusterrandomized, double-blind controlled study

Investigators from France, the UK, and Germany participated in a multicenter trial comparing oral ivermectin and malathion lotion to treat patients with head lice not eradicated by topical insecticide (pyrethroids and/or malathion) used two to six weeks before enrollment. Inclusion in the study required visual observation of lice after fine-toothed combing confirmed by study staff. Participants were at least 2 years of age and 15 kg in weight. Once an eligible child was identified, all infested members of the household (a cluster of up to six) were randomly assigned to a treatment …

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AAP Grand Rounds
Vol. 23, Issue 6
1 Jun 2010
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Difficult-to-Treat Head Lice
AAP Grand Rounds Jun 2010, 23 (6) 70; DOI: 10.1542/gr.23-6-70

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Difficult-to-Treat Head Lice
AAP Grand Rounds Jun 2010, 23 (6) 70; DOI: 10.1542/gr.23-6-70
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