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PICO
Study question: Among children who suffer traumatic brain injury, what percent will have some type of long-term endocrine dysfunction?
Question type: Prognosis
Study design: Prospective cohort
Investigators from Cincinnati Children’s Hospital Medical Center prospectively examined the incidence of endocrine dysfunction in children following moderate-to-severe traumatic brain injury (TBI). Study patients were enrolled one to five weeks after TBI. A variety of endocrine tests were obtained at multiple times after TBI. Moderate-to- severe TBI was defined as a post-resuscitation Glasgow Coma Score (GCS) ≤ 12.
Among 71 eligible study patients, 31 children aged 1.5 to 18 years were enrolled. Endocrine dysfunction was found in …
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