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PICO
Question: Among children with spina bifida undergoing clean intermittent catheterization, does antibiotic prophylaxis reduce the risk of urinary tract infection?
Question type: Intervention
Study design: Randomized controlled
A consortium of pediatricians in the Netherlands and Belgium conducted a randomized controlled trial examining whether low dose antibiotic prophylaxis reduces the risk of urinary tract infections (UTI) in children with spina bifida performing clean intermittent catheterization (CIC). Children meeting these criteria who were receiving antibiotic prophylaxis were randomized to continue or discontinue this prophylaxis, and followed for 18 months. Biweekly urine samples were tested for leukocyturia and bacteriuria by urine dipsticks and cultures. The results were categorized as asymptomatic significant bacteriuria …
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