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American Academy of Pediatrics
Allergy & Immunology

Growth of Preschool Children After Discontinuation of Fluticasone

AAP Grand Rounds February 2012, 27 (2) 16; DOI: https://doi.org/10.1542/gr.27-2-16
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Source: Guilbert TW, Mauger DT, Allen DB, et al. Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol. 2011; 128( 5): 956– 963; doi: 10.1016/j.jaci.2011.06.027OpenUrlCrossRef

PICO

Question: Among preschool children with wheezing, do daily inhaled corticosteroids have an effect on linear growth?

Question type: Intervention

Study design: Randomized controlled

A multicenter study by the National Institutes of Health Childhood Asthma Research and Education network (CARE) sought to determine the effect of daily inhaled corticosteroids (ICS) on linear growth in preschool children with recurrent wheezing. Children aged 24 to 35 months and 36 to 47 months were enrolled in a double-blind randomized, placebo-controlled parallel-group comparison of placebo with inhaled fluticasone at a total daily dose of 176 mcg/day delivered via Aero-Chamber with mask. Children were actively treated for two years, then followed for an additional two years. Height was measured every four months during …

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AAP Grand Rounds
Vol. 27, Issue 2
1 Feb 2012
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Growth of Preschool Children After Discontinuation of Fluticasone
AAP Grand Rounds Feb 2012, 27 (2) 16; DOI: 10.1542/gr.27-2-16

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Growth of Preschool Children After Discontinuation of Fluticasone
AAP Grand Rounds Feb 2012, 27 (2) 16; DOI: 10.1542/gr.27-2-16
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