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American Academy of Pediatrics
International Child Health

A Malaria Vaccine: Promising Results, but Not There Yet

AAP Grand Rounds March 2012, 27 (3) 26; DOI: https://doi.org/10.1542/gr.27-3-26
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Source: The RTS,S Clinical Trials Partnership. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011; 365( 20): 1863– 1875; doi: 10.1056/NEJMoa1102287OpenUrlCrossRefPubMed

PICO

Question: Among 6-week- to 17-month-old children, is the RTS malaria vaccine safe and does it protect against malaria?

Question type: Intervention

Study design: Randomized clinical trial

An international group of researchers performed this double-blind, randomized trial involving eleven centers in seven African countries to determine the efficacy, safety, and immunogenicity of RTS,S/AS01, a candidate malaria vaccine in infants and young children. The vaccine is a recombinant vaccine in which the malaria protein is fused to the hepatitis B surface antigen. After enrollment in the study, children were divided into two age groups: 6 to 12 weeks (6,537 participants) and 5 to 17 months (8,923 participants).

Children in each group were then randomly assigned to three doses of the vaccine at one-month intervals; a control group received a non-malaria vaccine. In the 6 to 12 weeks age group, the control vaccine was a meningococcal C conjugate …

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AAP Grand Rounds
Vol. 27, Issue 3
1 Mar 2012
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A Malaria Vaccine: Promising Results, but Not There Yet
AAP Grand Rounds Mar 2012, 27 (3) 26; DOI: 10.1542/gr.27-3-26

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A Malaria Vaccine: Promising Results, but Not There Yet
AAP Grand Rounds Mar 2012, 27 (3) 26; DOI: 10.1542/gr.27-3-26
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