This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
PICO
Question: Among 6-week- to 17-month-old children, is the RTS malaria vaccine safe and does it protect against malaria?
Question type: Intervention
Study design: Randomized clinical trial
An international group of researchers performed this double-blind, randomized trial involving eleven centers in seven African countries to determine the efficacy, safety, and immunogenicity of RTS,S/AS01, a candidate malaria vaccine in infants and young children. The vaccine is a recombinant vaccine in which the malaria protein is fused to the hepatitis B surface antigen. After enrollment in the study, children were divided into two age groups: 6 to 12 weeks (6,537 participants) and 5 to 17 months (8,923 participants).
Children in each group were then randomly assigned to three doses of the vaccine at one-month intervals; a control group received a non-malaria vaccine. In the 6 to 12 weeks age group, the control vaccine was a meningococcal C conjugate …
Individual Login
Institutional Login
You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.
Log in through your institution
Purchase access
In this issue
Jump to section
Related Articles
Cited By...
- No citing articles found.