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PICO
Question: Among children vaccinated with DTaP-IPV-HiB at 3, 5, and 12 months, what is the risk of febrile seizures and epilepsy?
Question type: Causation
Study design: Population-based cohort
Investigators from the University of California, Los Angeles, Aarhus University, and other centers in Denmark examined the risk of febrile seizures and epilepsy after vaccination with the combined diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus-Haemophilus influenza type b (DTaP-IPV-Hib) vaccine given at 3, 5, and 12 months. A cohort of 378,834 children born in Denmark between 2003 and 2008 were followed through 2009. Outcome measures were International Statistical Classification of Diseases, Tenth Revision diagnoses of febrile seizures within 0 to 7 days after each DTaP-IPV-Hib vaccination and epilepsy during the 7-year follow-up of the cohort. The …
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