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PICO
Question: Among children 3 years of age, does antenatal treatment of maternal hypothyroidism improve cognitive outcome?
Question type: Intervention
Study design: Randomized controlled
Investigators from the United Kingdom and Italy conducted a randomized controlled trial to determine if prenatal screening for and treatment of maternal hypothyroidism improves childhood cognitive function. Pregnant women at a gestation of 15 weeks 6 days or less provided blood samples for measurement of thyrotropin and free thyroxin (T4). Women were subsequently randomly assigned to a screening group or control group. Samples from women in the screening group were immediately assayed and those who had positive findings, defined as thyrotropin …
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