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PICO
Question: Among US children aged 4 to 6 years, do measles-containing vaccines lead to an increased risk of febrile seizures?
Question type: Intervention
Study design: Retrospective cohort
Investigators from the Centers for Disease Control and Prevention (CDC) and 7 managed care organizations (MCOs) participating in the Vaccine Safety Datalink evaluated the risk of febrile seizure and medically-attended fever events among US children aged 4 to 6 years in the 6 weeks following receipt of either measles-mumps-rubella-varicella vaccine (MMRV), separately administered MMR + V vaccines given on the same day, or MMR or V given alone. Study participants were children in 1 of the 7 MCOs who received 1 of these vaccines …
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