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PICO
Question: Among infants, does Ara h 2 antigen testing accurately diagnose peanut allergy?
Question type: Diagnosis
Study design: Randomized controlled
Researchers from the HealthNuts study group in Australia conducted a multicenter study to determine whether Ara h 2-specific immunoglobulin E (sIgE) measurement could be used to improve the accuracy of peanut allergy diagnosis and eliminate the need for oral food challenges (OFC) in infants with positive skin prick testing (SPT) for peanuts. Ara h 2 is the dominant peanut allergen, and Ara h 2 sIgE has been previously identified in over 90% of peanut-allergic individuals.1 Study participants were children aged 11 to 15 months who had previously been enrolled in the population-based Health- Nuts project. For …
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