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PICO
Question: Among patients undergoing CT for possible appendicitis, is low-dose CT as accurate as standard-dose CT for diagnosis of appendicitis?
Question type: Diagnosis
Study design: Randomized noninferiority
Investigators in Seoul, Korea conducted a randomized, “noninferiority” study to determine if low-dose (2 mSv) CT is as accurate as standard-dose (8 mSv) CT in patients suspected of having acute appendicitis upon presentation to an emergency department (ED). Patients 15 to 44 years of age were enrolled when imaging was deemed necessary based on clinical signs and symptoms. They were randomly assigned to low- or standard-dose CT and all received IV contrast. Appendicitis was diagnosed based on pathology reports for participants who underwent surgery, and chart review plus phone follow-up 3 months after initial presentation for those who did not have surgery. The primary outcome was the …
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