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PICO
Question: Among newborns with hypoxicischemic encephalopathy, does therapeutic hypothermia affect the MRI pattern of white matter injury as compared to normothermia?
Question type: Intervention
Study design: Randomized controlled
Investigators from the Infant Cooling Evaluation Collaboration, involving 28 centers in Australia, New Zealand, Canada, and the United States, sought to determine the effects of therapeutic hypothermia on the MRI of neonates with hypoxic-ischemic encephalopathy (HIE) and to evaluate the utility of MRI in predicting death and/or disability at age 2 years in patients with HIE. This study was part of a randomized controlled trial of the efficacy of 72 hours of whole-body hypothermia (target temperature, 33.5°C [range 33°C-34°C]) within the first 6 hours after birth in …
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