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PICO
Question: Among children whose parents smoked during pregnancy, does the duration and timing of parental smoking affect the risks of wheezing in early childhood?
Question type: Causation
Study design: Population-based prospective cohort
Investigators from the Netherlands examined the association between maternal and paternal smoking during pregnancy and the risk of early childhood wheezing. Data were collected as part of the Generation R Study,1 a large prospective cohort study in the Netherlands. Study children were born between 2002 and 2006. Mothers reported on smoking habits of both mother and father at the time of the first routine prenatal ultrasound. Smoking habits during second and third trimesters were assessed by follow-up questionnaires. Maternal smoking habits were …
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