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Investigators from Baylor College of Medicine conducted an observational study of pediatric patients admitted to the PICU from 2009 to 2010 with either confirmed or suspected influenza infection to assess the effect of bacterial co-infection on morbidity and mortality. Confirmed influenza infection was defined as any positive laboratory test for influenza A or B virus infection. Confirmed cases were further subtyped using PCR for H1N1, but this was incomplete since the study began prior to the introduction of PCR primers specific for H1N1. A clinically relevant bacterial co-infection was defined as: (1) empiric treatment of a clinical diagnosis of bacterial pneumonia, (2) bacterial super-infection within 72 hours of the initial PICU …
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