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PICO
Question: Among infants who have had major surgery, does intermittent IV acetaminophen decrease the need for morphine?
Question type: Intervention
Study design: Randomized controlled
Investigators from Rotterdam, the Netherlands conducted a randomized controlled trial to assess whether intermittent IV acetaminophen decreased morphine requirements in infants <1 year old undergoing thoracic or abdominal surgery. All enrolled patients received standardized anesthetic care and a loading dose of 100 μg/kg of morphine 30 minutes prior to termination of their surgery. Study infants were randomized to 1 of 2 treatment groups for receipt of medication after surgery: intermittent acetaminophen or continuous morphine. In order to minimize identification of treatment groups, infants randomized to the acetaminophen group received a continuous infusion …
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