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Question: Among children with diabetic ketoacidosis, does the rate of infusion of intravenous fluids affect the occurrence or severity of cerebral edema?
Question type: Intervention
Study design: Randomized controlled
Investigators from the University of California, Davis, sought to determine whether rehydration rate affects cerebral edema (CE) formation in children with diabetic ketoacidosis (DKA). Patients were eligible for the study if they were 8 to 18 years old, had type 1 diabetes, had DKA, and presented to the emergency department. DKA was defined as a serum glucose >300 mg/dL, venous pH <7.25 or bicarbonate <15 mEq/dL, and presence of urine ketones. Participants were randomized to either a rapid rehydration arm (20 cc/kg fluid bolus of 0.9% saline followed by two thirds of deficits replaced over 24 hours and one third over the following 24 hours …
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