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PICO
Question: Among children 5 to 16 years old admitted to the PICU, what is their neuropsychological function and academic performance compared to healthy controls 3 to 6 months following discharge?
Question type: Prognosis
Study design: Prospective cohort
Investigators from multiple institutions in the United Kingdom sought to determine whether children admitted to the PICU have neurocognitive functioning comparable to healthy controls 3 to 6 months following discharge. Children were eligible if they were 5 to 16 years old and admitted to one of 2 UK PICUs from 2007 to 2010. Children were excluded if they presented with a condition that likely had an effect on neuropsychological function (other than meningoencephalitis [ME] or sepsis) or had pre-existing neurologic disabilities, neurologic injury, or psychiatric disorders. Cases were categorized into 3 subgroups based on their diagnosis: ME, sepsis, or non-neurologic, non-septic (NNNS) …
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