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PICO
Question: Among children 6 months to 3 years old with head lice infestation, is 0.5% ivermectin lotion a safe treatment?
Question type: Intervention
Study design: Open-label trial
Investigators at multiple sites conducted 2 safety studies of 0.5% ivermectin lotion, a treatment recently approved by the FDA for head lice in children ≥6 months old. The first safety study was an open-label, single- arm pharmacokinetic (PK) study in which children aged 6 months to 3 years with active head lice infestation were enrolled. Each child received treatment with a 10-minute application of ivermectin. Blood samples were collected at specific times for up to 15 days following treatment to measure the magnitude and duration of systemic absorption of ivermectin. Blood was also obtained for complete blood counts …
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