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PICO
Question: Among boys with Duchenne muscular dystrophy, does glucocorticoid treatment decrease the long-term incidence and progression of scoliosis?
Question type: Intervention
Study design: Prospective nonrandomized cohort
Investigators from the University of Toronto sought to determine if the long-term use of glucocorticoids in patients with Duchenne muscular dystrophy (DMD) resulted in a decreased incidence and progression of scoliosis and a decreased need for spinal surgery. Boys between ages 7 and 10 years with a diagnosis of DMD who were able to walk were enrolled in the study. The treatment group consisted of study participants whose parents consented to corticosteroid treatment; the control group consisted of boys whose parents elected not to use corticosteroids. …
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