Do Steroids Prevent Nephropathy in Henoch-Schönlein Purpura?

doi:10.1542/gr.30-6-63

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Source: Dudley J, Smith G, Llewelyn-Edwards A, et al. Randomized, double-blind, placebo-controlled trial to determine whether steroids reduce the incidence and severity of nephropathy in Henoch-Schönlein Purpura (HSP). Arch Dis Child. 2013; 98( 10): 756– 763; doi: 10.1136/archdischild-2013-303642OpenUrl Abstract/FREE Full Text

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Question: Among children with new-onset Henoch-Schönlein purpura, does a 2-week course of prednisolone compared to placebo decrease the presence of proteinuria at 1-year follow-up?

Question type: Intervention

Study design: Randomized controlled

Investigators from the United Kingdom conducted a multicenter, blinded, randomized trial in children ≤18 years of age with new-onset Henoch-Schönlein purpura (HSP) to determine if a 2-week course of prednisolone decreased the presence of proteinuria at 1-year follow-up, or the need for additional treatment during the 12-month study period. Children presenting to 1 of 24 participating centers in England and Wales with a diagnosis of HSP and fewer than 7 days of the characteristic rash were eligible for enrollment. Children were …

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