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PICO
Question: Among 4-month-old infants with moderate-to-severe eczema, what is the risk of egg allergy at 12 months of age after regular egg exposure from 4 to 8 months of age?
Question type: Causation
Study design: Randomized controlled
Investigators from multiple institutions in Australia sought to determine whether early egg exposure reduces the risk of subsequent IgE-mediated egg allergy in infants with eczema. They conducted a doubleblind, randomized controlled trial in which infants with moderate- to-severe eczema were allocated to receive 1 teaspoon of either pasteurized raw whole egg powder (intervention group) or rice powder (control group) daily from 4 to 8 months of age. A blood sample was obtained at randomization before exposure to the study powder to determine egg-specific IgE levels. …
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