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PICO
Question: Among adolescents with a history of childhood maltreatment and/or psychopathology, does the size of the amygdala and hippocampus differ compared to children without such a history?
Question type: Harm/progression
Study design: Prospective cohort
To examine the effect of childhood maltreatment on brain development and evaluate whether psychopathology altered that effect, investigators from Australia used magnetic resonance imaging (MRI) to study development of the hippocampus and amygdala in adolescents. For the project, a cohort of adolescents were recruited from the Adolescent Development Study (a study of adolescent response to emotional and behavior problems in Melbourne, Australia). Participants were excluded if they had any preexisting psychopathology, substance use, eating disorder, learning disability, or chronic illness, or had used medications known to affect brain functioning. Participants completed the Childhood Trauma Questionnaire (CTQ) at baseline and follow-up. …
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