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PICO
Question: Among patients 6 months to 20 years of age with staphylococcal skin and soft tissue infections, what percentage are colonized with a strain that matches the infecting strain and what percentage of household contacts are colonized with the same strain?
Question type: Harm/Causation
Study design: Prospective cohort
Investigators from Washington University, St Louis, sought to determine if staphylococcal skin and soft tissue infections (SSTI) in children were acquired endogenously or from household members. Eligible patients (cases) were between 6 months and 20 years of age with a culture-confirmed methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible S aureus (MSSA) SSTI and were also colonized with S aureus in the anterior nares, axillae, or …
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