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PICO
Question: Among children with newly diagnosed attention-deficit/hyperactivity disorder, what is the efficacy of ωfatty acids alone compared to methylphenidate alone and methylphenidate with ωfatty acids?
Question type: Intervention
Study design: Randomized trial
Investigators at the Federico Gómez Children’s Hospital of Mexico conducted a randomized, unblinded pilot study comparing the efficacy of ω-3/6 fatty acids (ω-3/6) alone, long-acting methylphenidate (MPH) alone, and a combination of MPH and ω-3/6 for the treatment of newly diagnosed attention-deficit/hyperactivity disorder (ADHD) in children 6 to 12 years old. Study participants were randomized to 1 of the 3 treatment groups. Those in an ω-3/6 treatment group received a mixture of 558 mg ω-3 eicosapentaenoic acid (EPA), 174 mg ω-3 docosahexaenoic acid (DHA), and 60 mg ω-6 gamma-linolenic acid (GLA) daily. Those randomized to a MPH treatment group …
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