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PICO
Question: Among critically ill children, does high-flow nasal cannula decrease work of breathing in patients with respiratory distress?
Question type: Intervention
Study design: Prospective cohort
Investigators from the Children’s Hospital Los Angeles sought to evaluate the effect of high-flow nasal cannula (HFNC) on work of breathing in critically ill children. Children were eligible for enrollment if they were under 18 years of age, were hospitalized in the ICU, and were either receiving high-flow nasal cannula (HFNC) at the time of enrollment or their care plan included use of HFNC after extubation.
Esophageal pressure (Pes), a surrogate for pleural pressure, was measured using a Pes monitoring catheter. Pes and respiratory rate (RR) measurements were recorded at baseline and while on HFNC adjusted to 2, 5, and 8 L/minute …
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