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PICO
Question: Among infants with biliary atresia who have the Kasai hepatoportoenterostomy, does treatment with postoperative steroids result in improved outcomes compared with placebo?
Question type: Intervention
Study design: Prospective randomized controlled
Investigators from the Childhood Liver Disease Research and Education Network (ChiLDREN), a North American multicentered consortium, conducted a double-blind, placebo-controlled randomized trial to evaluate whether postoperative corticosteroids were associated with improved outcomes among patients with biliary atresia (BA) following the Kasai hepatoportoenterostomy (HPE). The Steroids in Biliary Atresia Randomized Trial (START) was carried out between 2005 and 2011 and involved randomizing participants to receive either high-dose corticosteroids or placebo starting within 72 hours following HPE. Participants …
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