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PICO
Question: Among adolescents and young adults, what was the effect of the FDA warning of an increased risk of suicidality with antidepressant use on suicidal behavior and antidepressant use?
Question type: Harm
Study design: Interrupted time series
Investigators from multiple institutions sought to determine whether the FDA black box warning for increased suicide risk with antidepressant use among adolescents changed use of these medications and suicidal behavior. Study data were obtained from an automated data system that includes 11 HMOs providing care to 10 million people in 12 states. Study cohorts included adolescents (aged 10–17 years), young adults (aged 18–29), and adults (aged 30–64) for whom there were available data. Since adults were not the target of the FDA warning, they were …
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